Home » NFL Week 14: Seattle Seahawks vs. San Francisco 49ers betting picks, preview

NFL Week 14: Seattle Seahawks vs. San Francisco 49ers betting picks, preview

These two NFC West rivals just met on Thanksgiving, and now we’re right back to them when the Seattle Seahawks visit the San Francisco 49ers. The Niners have had the Hawks number of late. Is anything going to change this Sunday?

Seattle Seahawks vs. San Francisco 49ers: Betting Odds

Spread: San Francisco -11, Over/under: 46.5 points, Seattle +455 | San Francisco -625

San Francisco is off the signature win of the season, a 42-19 thumping of the Philadelphia Eagles on the road. That win has moved San Francisco to 9-3 and secured them as the betting favorites to win the Super Bowl.

Brock Purdy and this loaded offense are humming on all cylinders, and the defense is playing some terrific ball during this four-game winning streak.